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Yi-Hau Chen

2012-07-24
11:10:00 - 12:00:00

308 , Mathematics Research Center Building (ori. New Math. Bldg.)

The generalized estimating equation (GEE) has been a popular tool for marginal regression analysis with longitudinal data, and its extension, the weighted GEE approach, can further accommodate data that are missing at random (MAR). Model selection methodologies for GEE, however, have not been systematically developed to allow for missing data. We propose the missing longitudinal information criterion (MLIC) for selection of the mean model and the correlation structure in GEE when the outcome data are subject to dropout/monotone missingness and are MAR. Our simulation results reveal that the new proposal is effective for variable selection in the mean model and selecting the correlation structure. We also demonstrate the remarkable drawbacks of naively treating incomplete data as if they were complete and applying the existing GEE model selection method. The utility of proposed method is further illustrated by real applications involving missing longitudinal outcome data. This is a joint work with Dr. 沈 仲維 at Academia Sinica.